CHDR Annual Report 2024
Scientific output

Our publications in 2024

  • Wildenbeest FWH, Hassing GJ, Kemme MJB, et al. Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers. Clin Physiol Funct Imaging. 2024 Jan;44(1):36-43. doi: 10.1111/cpf.12846. Epub 2023 Aug 7. PMID: 37458374.
  • Meijer RPJ, Galema HA, Faber RA, et al. Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study. Eur J Nucl Med Mol Imaging. 2024 Aug;51(10):2970-2979. doi: 10.1007/s00259-023-06365-3. Epub 2023 Aug 8. PMID: 37552367; PMCID: PMC11300526.
  • Heck J, Höner Zu Siederdissen C, Krause O, et al. Concordance of emergency department physicians' decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study. Int Health. 2024 Mar 4;16(2):219-226. doi: 10.1093/inthealth/ihad076. PMID: 37624102; PMCID: PMC10911529.
  • Houvast RD, Badr N, March T, et al. Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer. Eur J Nucl Med Mol Imaging. 2024 Jul;51(8):2179-2192. doi: 10.1007/s00259-023-06407-w. Epub 2023 Aug 29. PMID: 37642704; PMCID: PMC11178671.
  • Dijkstra FM, Zuiker RGJA, Heuberger JAAC, et al. Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo-hallucinations. Br J Clin Pharmacol. 2024 Jan;90(1):321-335. doi: 10.1111/bcp.15910. Epub 2023 Oct 11. PMID: 37724688.
  • Rousel J, Bergmans ME, van der Meulen LWJ, et al. Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebo-controlled exploratory clinical trial. J Am Acad Dermatol. 2024 Feb;90(2):395-397. doi: 10.1016/j.jaad.2023.09.071. Epub 2023 Oct 5. PMID: 37804933.
  • Bekkers VZ, Khan F, Aarts P, et al. Needle-free electronically-controlled jet injector treatment with bleomycin and lidocaine is effective and well-tolerated in patients with recalcitrant keloids. Lasers Surg Med. 2024 Jan;56(1):45-53. doi: 10.1002/lsm.23737. Epub 2023 Nov 7. PMID: 37933762.
  • van Kraaij SJW, Hamblin MR, Pickering G, et al. A Phase 1 randomized, open-label clinical trial to evaluate the effect of a far-infrared emitting patch on local skin perfusion, microcirculation and oxygenation. Exp Dermatol. 2024 Jan;33(1):e14962. doi: 10.1111/exd.14962. Epub 2023 Nov 10. PMID: 37950549.
  • Goncalves LN, van Velze V, Klok FA, et al. High on-treatment platelet reactivity in peripheral arterial disease: A systematic review. Vascular. 2024 Dec;32(6):1177-1190. doi: 10.1177/17085381231214324. Epub 2023 Nov 11. PMID: 37950666.
  • Rousel J, Nădăban A, Saghari M, et al. Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition. Exp Dermatol. 2024 Jan;33(1):e14952. doi: 10.1111/exd.14952. Epub 2023 Nov 16. PMID: 37974545.
  • Yfanti C, Vestbjerg B, Van't Westende J, et al. A phase 1 trial of AP30663, a K<sub>Ca</sub>2 channel inhibitor in development for conversion of atrial fibrillation. Br J Clin Pharmacol. 2024 Apr;90(4):1027-1035. doi: 10.1111/bcp.15973. Epub 2024 Jan 8. PMID: 37990600.
  • van Huizen A, Bank P, van der Kraaij G, et al. Quantifying the Effect of Methotrexate on Adalimumab Response in Psoriasis by Pharmacokinetic-Pharmacodynamic Modeling. J Invest Dermatol. 2024 Apr;144(4):794-801.e6. doi: 10.1016/j.jid.2023.10.022. Epub 2023 Nov 20. PMID: 37992959.
  • Noubissi FK, Odubanjo OV, Ogle BM, et al. Mechanisms of Cell Fusion in Cancer. Results Probl Cell Differ. 2024;71:407-432. doi: 10.1007/978-3-031-37936-9_19. PMID: 37996688; PMCID: PMC10893907.
  • Wu S, Huisman BW, Rietveld MH, et al. The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy. Cell Oncol (Dordr). 2024 Jun;47(3):883-896. doi: 10.1007/s13402-023-00902-w. Epub 2023 Dec 7. PMID: 38057628.
  • Peil J, Vossen C, Bock F, et al. Combined Osteopontin Blockade and Type 2 Classical Dendritic Cell Vaccination as Effective Synergetic Therapy for Conjunctival Melanoma. J Immunol. 2024 Feb 1;212(3):487-499. doi: 10.4049/jimmunol.2300063. PMID: 38099710.
  • Cremers S, Tucker GT, Aronson JK. The British Journal of Clinical Pharmacology: The first 50 years. Br J Clin Pharmacol. 2024 Jan;90(1):4-11. doi: 10.1111/bcp.15952. PMID: 38153173.
  • Prins MLM, Roozen GVT, Pothast CR. Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial. NPJ Vaccines. 2024 Jan 2;9(1):1. doi: 10.1038/s41541-023-00785-w. PMID: 38167735.
  • Jansen SC, van Lemmen M, Olofsen E. Reversal of Propofol-induced Depression of the Hypoxic Ventilatory Response by BK-channel Blocker ENA-001: A Randomized Controlled Trial. Anesthesiology. 2024 Jun 1;140(6):1076-1087. doi: 10.1097/ALN.0000000000004915. PMID: 38241294.
  • Corti N, Chiu C, Cox RJ. Regulatory workshop on challenge strain development and GMP manufacture - A stakeholder meeting report. Biologicals. 2024 Feb;85:101746. doi: 10.1016/j.biologicals.2024.101746. Epub 2024 Feb 3. PMID: 38309984.
  • Wilschut ED, de Winter EP, Bos EJ. Supervised Pre-Operative Forearm Exercise to Increase Blood Vessel Diameter in Haemodialysis Patients: The PINCH Trial. Eur J Vasc Endovasc Surg. 2024 May;67(5):852-853. doi: 10.1016/j.ejvs.2024.01.090. PMID: 38316352.
  • Kapulu M, Manda-Taylor L, Balasingam S. Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023. Biologicals. 2024 Feb;85:101747. doi: 10.1016/j.biologicals.2024.101747. Epub 2024 Feb 13. PMID: 38350825.
  • Pearson TA, Vitalis D, Pratt C. The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities. JACC Adv. 2024 Jan;3(1):100759. doi: 10.1016/j.jacadv.2023.100759. PMID: 38375059.
  • Rousel J, Mergen C, Schoones JW. Similar Alterations of the Stratum Corneum Ceramide Profile in Atopic Dermatitis, Psoriasis, and Ichthyosis: Results from a Systematic Review and Meta-Analysis. J Invest Dermatol. 2024 Oct;144(10):2311-2314.e22. doi: 10.1016/j.jid.2024.02.010. Epub 2024 Mar 4. PMID: 38447864.
  • Eveleens Maarse BC, Eggink HM, Warnke I. Impact of fibre supplementation on microbiome and resilience in healthy participants: A randomized, placebo-controlled clinical trial. Nutr Metab Cardiovasc Dis. 2024 Jun;34(6):1416-1426. doi: 10.1016/j.numecd.2024.01.028. PMID: 38499450.
  • Skov M, Ruijs TQ, Grønnebæk TS. The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Sci Transl Med. 2024 Mar 20;16(739):eadk9109. doi: 10.1126/scitranslmed.adk9109. PMID: 38507469.
  • Jodl SJ, Ten Voorde W, Klein S. The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers. Clin Transl Sci. 2024 Mar;17(3):e13771. doi: 10.1111/cts.13771. PMID: 38511583.
  • Post TE, Denney C, Cohen A. Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research. Br J Clin Pharmacol. 2024 Mar 31. doi: 10.1111/bcp.16040. PMID: 38556349.
  • Achterberg FB, Bijlstra OD, Slooter MD. ICG-Fluorescence Imaging for Margin Assessment During Minimally Invasive Colorectal Liver Metastasis Resection. JAMA Netw Open. 2024 Apr 1;7(4):e246548. doi: 10.1001/jamanetworkopen.2024.6548. PMID: 38639939.
  • Cárdenas V, Le Gars M, Truyers C. Safety and immunogenicity of Ad26.COV2.S in adults: A randomised, double-blind, placebo-controlled Phase 2a dose-finding study. Vaccine. 2024 Jun 11;42(16):3536-3546. doi: 10.1016/j.vaccine.2024.04.059. PMID: 38705804.
  • Thijssen E, Tuk B, Cakici M. Clinical trial evaluating apomorphine oromucosal solution in Parkinson's disease patients. Clin Transl Sci. 2024 May;17(5):e13796. doi: 10.1111/cts.13796. PMID: 38712716.
  • Eveleens Maarse BC, Ronner MN, Jansen MAA, et al. Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses - a randomized, placebo-controlled clinical trial. Immunol Res. 2024 Aug;72(4):776-787. doi: 10.1007/s12026-024-09484-7. Epub 2024 May 15. PMID: 38748319; PMCID: PMC11347467.
  • van der Plas JL, Haijema BJ, Leenhouts K, et al. Safety, reactogenicity and immunogenicity of an intranasal seasonal influenza vaccine adjuvanted with gram-positive matrix (GEM) particles (FluGEM): A randomized, double-blind, controlled, ascending dose study in healthy adults and elderly. Vaccine. 2024 Sep 17;42(22):125836. doi: 10.1016/j.vaccine.2024.03.063. Epub 2024 May 20. PMID: 38772837.
  • van Kraaij S, Goeldner RG, Rosenbrock H, et al. Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies. Br J Clin Pharmacol. 2024 Oct;90(10):2517-2528. doi: 10.1111/bcp.16137. Epub 2024 Jun 16. PMID: 38880932.
  • Eijsvogel P, Misra P, Concha-Marambio L, et al. Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial. Nat Med. 2024 Sep;30(9):2631-2640. doi: 10.1038/s41591-024-03101-8. Epub 2024 Jun 20. PMID: 38902546; PMCID: PMC11405261.
  • In 't Veld AE, Eveleens Maarse BC, Juachon MJ, et al. Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T-cell proliferation but residual T-cell activity during maintenance immunosuppressive treatment. Clin Transl Sci. 2024 Jun;17(6):e13860. doi: 10.1111/cts.13860. PMID: 38923308; PMCID: PMC11197031.
  • Neijenhuis LKA, Naumann LL, Ferkel SAM, et al. Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma. Oncol Res. 2024 Jun 20;32(7):1163-1172. doi: 10.32604/or.2024.050907. PMID: 38948019; PMCID: PMC11209741.
  • Gorbenko AA, Cohen AA, et al. On the use of open-label studies for the evaluation of cannabis-based products for the treatment of long COVID. Br J Clin Pharmacol. 2024 Jul 4. doi: 10.1111/bcp.16169. Epub ahead of print. PMID: 38964752.
  • Koopmans I, Geerse D, de Ridder L, et al. The interactive walkway provides fit-for-purpose fall-risk biomarkers in the elderly: Comparison of zolpidem and suvorexant. Clin Transl Sci. 2024 Jul;17(7):e13875. doi: 10.1111/cts.13875. PMID: 38978326; PMCID: PMC11231031.
  • Rousel J, Mergen C, Bergmans ME, et al. Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial. J Lipid Res. 2024 Aug;65(8):100591. doi: 10.1016/j.jlr.2024.100591. Epub 2024 Jul 9. PMID: 38992724; PMCID: PMC11342092.
  • Soegiharto R, Alizadeh Aghdam M, Sørensen JA, et al. Multinational Drug Survival Study of Omalizumab in Patients With Chronic Urticaria and Potential Predictors for Discontinuation. JAMA Dermatol. 2024 Sep 1;160(9):927-935. doi: 10.1001/jamadermatol.2024.2056. Erratum in: JAMA Dermatol. 2024 Nov 1;160(11):1257. doi: 10.1001/jamadermatol.2024.4573. PMID: 39018068; PMCID: PMC11255966.
  • Bekkers VZ, Zdunczyk KM, Bik L, et al. Needle-free jet injector treatment with bleomycin is efficacious in patients with severe keloids: a randomized, double-blind, placebo-controlled trial. Clin Exp Dermatol. 2024 Nov 22;49(12):1668-1675. doi: 10.1093/ced/llae254. PMID: 39030712
  • Gorbenko AA, Heuberger JAAC, Klumpers LE, et al. Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ9-Tetrahydrocannabinol Without Improving Its Analgesic Properties. Clin Pharmacol Ther. 2024 Nov;116(5):1289-1303. doi: 10.1002/cpt.3381. Epub 2024 Jul 25. PMID: 39054656.
  • Nieuwenhoff MD, Nguyen HT, Niehof SP, et al. Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy. Muscle Nerve. 2024 Oct;70(4):782-790. doi: 10.1002/mus.28213. Epub 2024 Jul 26. PMID: 39056231.
  • Voorde WT, Wind S, Abdisalaam I, et al. A suction blister model to characterize epidermal wound healing and evaluate the efficacy of the topical wound healing agent INM-755 in healthy volunteers. Eur J Pharm Sci. 2025 Jan 1;204:106867. doi: 10.1016/j.ejps.2024.106867. Epub 2024 Jul 29. PMID: 39084539.
  • Albalak G, Noordam R, van der Elst M, et al. Older adults exercising ON TIME: protocol for a randomized controlled cross-over study to assess the effect of physical activity timing on insomnia severity. Trials. 2024 Aug 5;25(1):523. doi: 10.1186/s13063-024-08310-7. PMID: 39103937; PMCID: PMC11299269.
  • van den Noort JA, Assil S, Ronner MN, et al. Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development. Inflammation. 2024 Aug 26. doi: 10.1007/s10753-024-02127-x. Epub ahead of print. PMID: 39183259.
  • Eijsvogel PPNM, Borghans LGJM, Prins S, et al. Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's Disease. J Parkinsons Dis. 2024;14(6):1149-1161. doi: 10.3233/JPD-240039. PMID: 39213090; PMCID: PMC11380312.
  • Boyle Y, Hijma HJ, Rees J, et al. Randomized, placebo-controlled study on the effects of intravenous GSK3858279 (anti-CCL17) on a battery of evoked pain tests in healthy participants. Clin Transl Sci. 2024 Sep;17(9):e13873. doi: 10.1111/cts.13873. PMID: 39250326; PMCID: PMC11382652.
  • Lauwerends LJ, Zweedijk BE, Galema HA, et al. Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging. Mol Diagn Ther. 2024 Nov;28(6):811-820. doi: 10.1007/s40291-024-00742-w. Epub 2024 Sep 9. PMID: 39251469; PMCID: PMC11512873.
  • Powell WR, Chamberlain L, Buckingham WR, et al. Evaluating Policy Changes for Adjusting Payment to Address Health Disparities. JAMA Health Forum. 2024 Sep 6;5(9):e242905. doi: 10.1001/jamahealthforum.2024.2905. PMID: 39269695; PMCID: PMC11400218.
  • Yin Q, Wolkerstorfer A, Lapid O, et al. KECORT Study: An International e-Delphi Study on the Treatment of KEloids Using Intralesional CORTicosteroids in Clinical Practice. Am J Clin Dermatol. 2024 Nov;25(6):1009-1017. doi: 10.1007/s40257-024-00888-7. Epub 2024 Sep 19. PMID: 39298112; PMCID: PMC11511692.
  • van Kraaij SJW, Eveleens Maarse BC, Hoevenaars FPM, et al. Microvascular effects of a mixed meal tolerance test: a model validation study. Clin Physiol Funct Imaging. 2025 Jan;45(1):e12904. doi: 10.1111/cpf.12904. Epub 2024 Sep 23. PMID: 39308427; PMCID: PMC11650408.
  • van Ruissen MCE, van Kraaij SJW, Gal P, et al. Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress. J Exp Pharmacol. 2024 Sep 17;16:285-294. doi: 10.2147/JEP.S473217. PMID: 39308849; PMCID: PMC11416113.
  • Linders DGJ, Bijlstra OD, Fallert LC, et al. Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients. Mol Imaging Biol. 2024 Dec;26(6):1057-1067. doi: 10.1007/s11307-024-01955-5. Epub 2024 Sep 27. PMID: 39331316; PMCID: PMC11634923.
  • de Jong LM, Harpal C, Berg DVD, et al. CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation. Drug Metab Dispos. 2024 Nov 15;52(12):1429-1437. doi: 10.1124/dmd.124.001867. PMID: 39349298.
  • Soegiharto R, Alizadeh Aghdam M, Sørensen JA, et al. Omalizumab is effective and safe in chronic inducible urticaria (CIndU): Real-world data from a large multi-national UCARE study. Allergy. 2025 Feb;80(2):489-499. doi: 10.1111/all.16334. Epub 2024 Oct 8. PMID: 39377745; PMCID: PMC11804303.
  • Rousel J, Mergen C, Bergmans ME, et al. Lesional Psoriasis is Associated With Alterations in the Stratum Corneum Ceramide Profile and Concomitant Decreases in Barrier Function. Exp Dermatol. 2024 Oct;33(10):e15185. doi: 10.1111/exd.15185. PMID: 39382258.
  • Linders DGJ, Bijlstra OD, Walker E, et al. Ex vivo fluorescence-guided resection margin assessment in breast cancer surgery using a topically applied, cathepsin-activatable imaging agent. Pharmacol Res. 2024 Nov;209:107464. doi: 10.1016/j.phrs.2024.107464. Epub 2024 Oct 12. PMID: 39401538.
  • Stuijt DG, van Doeveren EEM, Kos M, et al. Remote Patient Monitoring Using Mobile Health Technology in Cancer Care and Research: Patients' Views and Preferences. JCO Clin Cancer Inform. 2024 Nov;8:e2400092. doi: 10.1200/CCI.24.00092. Epub 2024 Nov 12. PMID: 39531613; PMCID: PMC11573098.
  • Houvast RD, van Duijvenvoorde M, Thijse K, et al. Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation. Mol Diagn Ther. 2025 Mar;29(2):213-227. doi: 10.1007/s40291-024-00755-5. Epub 2024 Nov 14. PMID: 39541080; PMCID: PMC11860997.
  • Galema HA, Neijenhuis LKA, Lauwerends LJ, et al. Effects of Neoadjuvant Therapy on Tumour Target Expression of Oesophageal Cancer Tissue for NIR Fluorescence Imaging. Mol Imaging Biol. 2024 Dec;26(6):955-964. doi: 10.1007/s11307-024-01962-6. Epub 2024 Nov 19. PMID: 39562416.
  • Osanto S, Vliert-Bout AV, Gomez de Segura CA, et al. Health-related quality of life outcomes in randomized controlled trials in metastatic hormone-sensitive prostate cancer: a systematic review. EClinicalMedicine. 2024 Nov 13;78:102914. doi: 10.1016/j.eclinm.2024.102914. PMID: 39619239; PMCID: PMC11605133.
  • Magliocca M, Koopmans I, Vaillant C, et al. Nighttime safety of daridorexant: Evaluation of responsiveness to an external noise stimulus, postural stability, walking, and cognitive function. J Psychopharmacol. 2025 Mar;39(3):223-232. doi: 10.1177/02698811241293997. Epub 2024 Dec 6. PMID: 39641404; PMCID: PMC11843790.
  • de Cuba CMKE, de Goede AA, Klaassen ES, et al. TMS and EEG Pharmacodynamic Effects of a Selective Sphingosine-1-Phosphate Subtype 1 Receptor Agonist on Cortical Excitability in Healthy Subjects. Clin Pharmacol Ther. 2025 Mar;117(3):787-797. doi: 10.1002/cpt.3521. Epub 2024 Dec 6. PMID: 39641417; PMCID: PMC11835432.
  • Ruijs TQ, de Cuba CMKE, Heuberger JAAC, et al. Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial. Clin Pharmacol Ther. 2025 Mar;117(3):768-778. doi: 10.1002/cpt.3516. Epub 2024 Dec 9. PMID: 39651850; PMCID: PMC11835425.
  • van Dam CJ, Kramers C, Schellekens A, et al. Cannabis combined with oxycodone for pain relief in fibromyalgia pain: a randomized clinical self-titration trial with focus on adverse events. Front Pain Res (Lausanne). 2024 Nov 25;5:1497111. doi: 10.3389/fpain.2024.1497111. PMID: 39654798; PMCID: PMC11625723.
  • Janus A, Dumas D, Le Douce J, et al. Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study. Neurol Ther. 2025 Feb;14(1):357-377. doi: 10.1007/s40120-024-00691-w. Epub 2024 Dec 21. PMID: 39708220; PMCID: PMC11762061.
  • Cnossen VM, van Leeuwen RP, Mazur NI, et al. From setbacks to success: lessons from the journey of RSV vaccine development. Ther Adv Vaccines Immunother. 2024 Dec 19;12:25151355241308305. doi: 10.1177/25151355241308305. PMID: 39711948; PMCID: PMC11660060.
  • Hogenelst K, Krone T, Eveleens Maarse B, et al. A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study. Brain Behav Immun Health. 2024 Nov 28;43:100918. doi: 10.1016/j.bbih.2024.100918. PMID: 39717875; PMCID: PMC11665422.
  • Faber RA, Baart VM, Bordo MW, et al. Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging. Toxicol Appl Pharmacol. 2025 Feb;495:117222. doi: 10.1016/j.taap.2024.117222. Epub 2024 Dec 30. PMID: 39742926.
  • Faber RA, Meijer RPJ, Droogh DHM, et al. Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial. Lancet Gastroenterol Hepatol. 2024 Oct;9(10):924-934. doi: 10.1016/S2468-1253(24)00198-5. Epub 2024 Aug 13. PMID: 39151436.
  • Dijkhuis TH, Bijlstra OD, Warmerdam MI, et al. Semi-automatic standardized analysis method to objectively evaluate near-infrared fluorescent dyes in image-guided surgery. J Biomed Opt. 2024 Feb;29(2):026001. doi: 10.1117/1.JBO.29.2.026001. Epub 2024 Feb 1. PMID: 38312853; PMCID: PMC10833575.
  • Ehmann F, Kuhn A, Pasmooij AMG, et al. Report of the European Medicines Agency Conference on RNA-Based Medicines. Nucleic Acid Ther. 2024 Feb;34(1):4-11. doi: 10.1089/nat.2023.0021. Epub 2024 Jan 4. PMID: 38174996.
  • Hijma HJ, Zhuparris A, van Hoogdalem EJ, et al. Disproportional inflation of clinical trial costs: why we should care, and what we should do about it. Nat Rev Drug Discov. 2024 Feb;23(2):85-86. doi: 10.1038/d41573-024-00002-w. PMID: 38195708.

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